Skip to content
Brain and nerve healthDetected by MRI

Loss of deep gray-matter volume (subcortical atrophy)

Shrinkage of the brain's deep gray-matter structures (caudate, putamen, pallidum and thalamus), which help control movement, motivation and the relay of sensory signals. MRI volumetry measures this volume loss, which can be an early marker of neurodegenerative conditions such as Huntington's disease and some atypical Parkinson-type disorders.

Early detection matters

Our comprehensive check-up screens for loss of deep gray-matter volume (subcortical atrophy) and hundreds of other conditions.

Book check-upTalk to our team

Related biomarkers we test

Putamen volume

Normalized putamen volume as a proportion of total intracranial volume. This standardized measurement allows for more accurate detection of basal ganglia-specific changes independent of head size differences, which is important when evaluating movement disorders and certain neurodegenerative conditions.

Caudate volume

Normalized volume of the caudate nucleus relative to total intracranial volume, allowing for meaningful comparisons between individuals with different head sizes. This proportional measurement helps identify caudate-specific changes that may indicate neurodegenerative disorders affecting executive function and movement control.

Related conditions in Brain and nerve health