Albumin/globulin (A/G) ratio
Heart healthA calculated value comparing albumin (the main transport protein made by the liver) to globulins (a diverse group including antibodies, clotting factors, and inflammatory proteins).
Since albumin normally comprises about 60% of total protein and globulins 40%, this ratio reflects the balance between liver synthetic function, nutritional status, and immune/inflammatory activity.
Reference range
Source: Ahead Health benchmark
Reference ranges may vary between labs and assays. Always interpret results with your healthcare provider.
Why this matters
The A/G ratio provides diagnostic insight beyond individual protein measurements. A low ratio may indicate liver disease (reduced albumin production), chronic inflammation (elevated globulins from antibody production), autoimmune conditions, or multiple myeloma (abnormal immunoglobulin production). A high ratio suggests immunodeficiency or genetic disorders affecting globulin production. The ratio helps distinguish between conditions causing protein abnormalities: liver disease typically lowers the ratio by decreasing albumin, while chronic infections or autoimmune diseases lower it by increasing globulins.
Changes in the ratio often appear before total protein becomes abnormal, providing early detection of liver dysfunction, immune activation, or protein-losing conditions. It's particularly useful for monitoring chronic diseases and assessing the balance between protein synthesis and inflammatory burden.
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