Arachidonic acid (20:4, AA)
MetabolismAlso known as: AA, omega-6 arachidonic
AA is a polyunsaturated omega-6 fatty acid that serves as a precursor to numerous pro-inflammatory and vasoactive mediators.
Reference range
Source: lab benchmark
Reference ranges may vary between labs and assays. Always interpret results with your healthcare provider.
Why this matters
While essential for cell signaling and immune function, excessive Arachidonic Acid (AA) relative to omega-3s promotes chronic inflammation. Monitoring AA helps balance pro- and anti-inflammatory lipid pathways.
How this connects to other biomarkers
- Arachidonic Acid is the precursor to pro-inflammatory eicosanoids (PGE2, LTB4, TXA2) and is balanced against Eicosapentaenoic Acid (20:5, EPA) in the AA / EPA Ratio.
- Elevated AA with high AA / DGLA Ratio indicates active conversion to pro-inflammatory pathways; pair with hs-CRP to gauge clinical impact.
How often should I test Arachidonic acid (20:4, AA)?
Most adults benefit from yearly arachidonic acid (AA) testing as part of a fatty acid panel. After a sustained change in diet or supplementation, retest at 3 to 4 months.
At baseline / for screening: Once every 12 months as part of a fatty acid panel. More frequently, every 3 to 6 months, if you're managing a cardiometabolic concern where fatty acids matter.
When monitoring an intervention or change: Retest 3 to 4 months after a sustained change in dietary fat, such as increasing fatty fish, omega-3 supplements (EPA/DHA), or reducing seed oils. Red cell membranes take this long to fully reflect the new intake. Day-to-day variability is minimal, so only sustained dietary patterns shift the picture meaningfully; don't expect quick changes from short-term diet shifts.
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