Dihomo-gamma-linolenic acid (20:3, DGLA)
MetabolismAlso known as: DGLA
DGLA is a key omega-6 fatty acid formed from GLA.
It produces anti-inflammatory prostaglandins and acts as a metabolic balance point between GLA and arachidonic acid.
Why this matters
Higher DGLA levels are linked to reduced inflammation and improved immune balance. It plays an important role in moderating the effects of arachidonic acid.
How this connects to other biomarkers
- DGLA is a precursor to anti-inflammatory PGE1 and is elevated by Gamma-Linolenic Acid (18:3, GLA) intake (e.g. evening primrose, borage).
- The AA / DGLA Ratio indicates whether DGLA is being further desaturated to pro-inflammatory Arachidonic Acid (20:4, AA) — high ratios warrant addressing diet and insulin resistance (high HOMA-Index).
How often should I test Dihomo-gamma-linolenic acid (20:3, DGLA)?
Most adults benefit from yearly DGLA testing as part of a fatty acid panel. After a sustained change in diet or supplementation, retest at 3 to 4 months.
At baseline / for screening: Once every 12 months as part of a fatty acid panel. More frequently, every 3 to 6 months, if you're managing a cardiometabolic concern where fatty acids matter.
When monitoring an intervention or change: Retest 3 to 4 months after a sustained change in dietary fat, such as increasing fatty fish, omega-3 supplements (EPA/DHA), or reducing seed oils. Red cell membranes take this long to fully reflect the new intake. Day-to-day variability is minimal, so only sustained dietary patterns shift the picture meaningfully; don't expect quick changes from short-term diet shifts.
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