Docosapentaenoic acid (omega-3, DPA)
Omega fatty acidsDPA is a long-chain omega-3 fatty acid formed as an intermediate between EPA and DHA.
Also known as: DPA, clupanodonic acid, omega-3
It contributes to anti-inflammatory and endothelial-protective effects.
Why this matters
DPA plays a role in vascular repair and may enhance the overall anti-inflammatory benefits of the omega-3 family. Monitoring DPA helps evaluate total omega-3 status.
How this connects to other biomarkers
- Docosapentaenoic Acid is an omega-3 intermediate between EPA and DHA with independent anti-inflammatory and cardioprotective activity.
- Low DPA with low Eicosapentaenoic Acid (20:5, EPA) and Docosahexaenoic Acid (22:6, DHA) is part of the overall low-omega-3 pattern (low Omega-3 Index).
How often should I test Docosapentaenoic acid (omega-3, DPA)?
Most adults benefit from yearly DPA testing as part of a fatty acid panel. After a sustained change in diet or supplementation, retest at 3 to 4 months.
At baseline / for screening: Once every 12 months as part of a fatty acid panel. More frequently, every 3 to 6 months, if you're managing a cardiometabolic concern where fatty acids matter.
When monitoring an intervention or change: Retest 3 to 4 months after a sustained change in dietary fat, such as increasing fatty fish, omega-3 supplements (EPA/DHA), or reducing seed oils. Red cell membranes take this long to fully reflect the new intake. Day-to-day variability is minimal, so only sustained dietary patterns shift the picture meaningfully; don't expect quick changes from short-term diet shifts.
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