FIB-4 index
Stomach and gut healthFIB-4 combines age, platelet count, and liver enzymes to estimate the degree of liver fibrosis.
Reference range
01.33.3
Normal
Intermediate
High
Source: Ahead Health benchmark
Reference ranges may vary between labs and assays. Always interpret results with your healthcare provider.
Why this matters
FIB-4 identifies patients with significant liver fibrosis from conditions like non-alcoholic fatty liver disease, chronic hepatitis, or alcohol-related liver disease before symptoms appear. Early detection through FIB-4 screening enables lifestyle modifications (weight loss, alcohol cessation), medication adjustments, and closer monitoring to prevent progression to cirrhosis, liver failure, or hepatocellular carcinoma.
How this connects to other biomarkers
- FIB-4 > 2.67 indicates high risk for advanced liver scarring (fibrosis) and warrants further evaluation (FibroScan elastography, liver biopsy, or hepatology referral).
- Values 1.45–2.67 are inconclusive — interpret alongside metabolic markers (HOMA-Index, HbA1c (NGSP), Liver fat fraction (%PDFF), BMI) and patient context.
- In known liver disease, rising FIB-4 with falling Albumin and rising Bilirubin, total signals progression toward cirrhosis (advanced scarring with synthesis failure).
Included in
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