Globulin
Stomach and gut healthGlobulin is a group of proteins in the blood that includes immunoglobulins (antibodies), transport proteins, and complement proteins.
It is calculated by subtracting albumin from total protein. The albumin-to-globulin ratio helps assess liver function, kidney health, immune system activity, and nutritional status.
Reference range
Source: Ahead Health benchmark
Reference ranges may vary between labs and assays. Always interpret results with your healthcare provider.
Why this matters
Globulin levels reflect immune function, inflammatory status, and liver health. Elevated globulins indicate active immune response from infections, autoimmune diseases, chronic inflammation, or certain cancers like multiple myeloma. Low levels suggest immunodeficiency, protein loss, or severe liver dysfunction.
How this connects to other biomarkers
- Elevated Globulin with low Albumin/Globulin (A/G) Ratio points to widespread inflammation, autoimmune disease, or a monoclonal gammopathy (a single abnormal antibody-producing clone) — clarify with Immunofixation / Immunotyping and individual immunoglobulin levels (Immunoglobulin G, Immunoglobulin A, Immunoglobulin M).
- Low Globulin suggests an immune deficiency (e.g. common variable immunodeficiency, CVID) or selective protein loss.
Included in
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