Platelet-to-lymphocyte ratio
Immune system healthAlso known as: PLR, Thrombozyten-Lymphozyten-Quotient, trombocyt lymfocyt verhouding
PLR reflects the relationship between platelets which participate in clotting and inflammation and lymphocytes which support immune balance.
Why this matters
PLR serves as a simple yet powerful marker of systemic inflammation and immune balance. Elevated PLR indicates increased inflammatory burden and has been linked to poor outcomes in cardiovascular disease, cancer prognosis, and autoimmune conditions. It helps predict risk of heart attacks and strokes, as high ratios reflect both pro-thrombotic and pro-inflammatory states. Low PLR may suggest viral infections, certain blood disorders, or immunosuppression.
How often should I test Platelet-to-lymphocyte ratio?
Most adults benefit from yearly PLR reassessment as part of a CBC with differential.
At baseline / for screening: Once every 12 months from age 30 as part of a CBC with differential. More frequently if you have a chronic inflammatory condition.
When monitoring an intervention or change: These ratios are tracked alongside the CBC rather than on their own cadence. Retest with your next CBC after a sustained anti-inflammatory lifestyle change (better sleep, weight loss, Mediterranean-style diet). Single values are sensitive to acute illness, recent exercise, and stress, so test under consistent conditions.
Included in
Ready to check your health?
Get a comprehensive view of your biomarkers with our advanced check-up packages.