Progesterone
Men's/women's healthProgesterone is a hormone produced after ovulation and during pregnancy.
It plays a key role in regulating the menstrual cycle, preparing the uterus for pregnancy, and supporting early pregnancy. In non-pregnant women, progesterone drops trigger menstruation.
Why this matters
Progesterone levels reveal how well your reproductive system is functioning. Low progesterone can cause irregular periods, difficulty conceiving, or early pregnancy loss, while high levels outside pregnancy may indicate hormone imbalances or ovarian conditions. Maintaining a healthy lifestyle, managing stress, and working with a healthcare provider to monitor hormone levels helps support reproductive health and fertility.
How this connects to other biomarkers
- In women, day 21 (mid-luteal phase) Progesterone > 30 nmol/L confirms ovulation has occurred that cycle; persistently low values across the cycle suggest anovulation (failure to ovulate).
- Elevated Progesterone in non-pregnant, non-luteal samples can indicate adrenal sources or congenital adrenal hyperplasia (consider 17-OHP testing).
- Progesterone is a substrate for cortisol and aldosterone synthesis — chronic stress with elevated Cortisol can deplete progesterone ("pregnenolone steal").
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