Systemic immune-inflammation index (SII)
Immune system healthSII integrates neutrophil, platelet, and lymphocyte counts into a single measure of immune and inflammatory status.
Reference range
655
Normal
High
Source: Ahead Health benchmark
Reference ranges may vary between labs and assays. Always interpret results with your healthcare provider.
Why this matters
SII provides superior prognostic value compared to simpler ratios by incorporating platelet-mediated inflammation. Elevated SII predicts poor outcomes in cancer, cardiovascular disease, and severe infections.
How this connects to other biomarkers
- SII (Thrombocytes (Platelets) × Neutrophils (abs.) / Lymphocytes (abs.)) integrates three immune-inflammatory cell lines into a single prognostic marker.
- Elevated SII reflects active inflammation with reactive thrombocytosis and is associated with worse outcomes in cardiovascular disease, cancer, and infection.
- Use alongside NLR (Neutrophils/Lymphocytes) and Systemic Inflammation Response Index (SIRI) for a fuller integrated read.
Included in
Ready to check your health?
Get a comprehensive view of your biomarkers with our advanced check-up packages.