Testosterone / estradiol (T:E2) ratio
Men's/women's healthThis ratio evaluates the balance between testosterone and estradiol hormones in the body.
Why this matters
A healthy balance supports reproductive function, bone health, mood, and metabolic regulation. Abnormal ratios may suggest hormonal imbalances requiring attention.
How this connects to other biomarkers
- Testosterone-to-Estradiol ratio reflects how much testosterone is being converted to estrogen by the aromatase enzyme — a low ratio (more estrogen relative to testosterone) suggests excess conversion (obesity, alcohol, liver dysfunction with elevated Alanine Aminotransferase (ALAT)) or low testosterone production.
- In men with low Testosteron, total, a low T:E2 ratio further supports estrogen-mediated symptoms (breast tissue enlargement, fluid retention).
- In women, the ratio is interpreted alongside menstrual cycle phase and Sex hormone-binding globulin (SHBG).
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