TSH
Stomach and gut healthControls thyroid hormone production, which regulates metabolism and energy.
Thyroid dysfunction affects many body systems and can cause fatigue, weight changes, temperature sensitivity, and mood disturbances.
Why this matters
TSH levels rise when the thyroid is underactive (hypothyroidism) and fall when it is overactive (hyperthyroidism). Both conditions can affect energy, metabolism, weight, mood, and heart function. Monitoring TSH helps detect thyroid imbalance early, often before symptoms become obvious, allowing timely treatment to maintain stable metabolism and overall health.
How this connects to other biomarkers
- TSH is the most sensitive screening test for thyroid dysfunction — the brain-thyroid feedback loop typically amplifies small thyroid hormone changes into large TSH shifts.
- Elevated TSH with low Free T4 (fT4) confirms primary hypothyroidism (underactive thyroid); with normal fT4 indicates subclinical hypothyroidism (treat if TSH > 10 or with antibodies/symptoms).
- Suppressed TSH with elevated Free T3 (fT3) / fT4 confirms primary hyperthyroidism (overactive thyroid); suppressed TSH with normal hormones indicates subclinical hyperthyroidism.
- Use the fT4 / TSH ratio when borderline or when central thyroid disease (a pituitary problem) is suspected.
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