AA / DGLA ratio
Omega fatty acidsAlso known as: arachidonic to DGLA ratio, delta-5 desaturase activity
This ratio reflects the conversion efficiency from DGLA to arachidonic acid and the balance between anti- and pro-inflammatory omega-6 metabolites.
Why this matters
A higher ratio suggests an inflammatory shift in omega-6 metabolism. Monitoring helps identify imbalances that may contribute to chronic inflammatory states.
How this connects to other biomarkers
- Elevated AA/DGLA Ratio reflects high delta-5-desaturase activity — it tilts the body toward production of pro-inflammatory eicosanoids and is associated with insulin resistance and metabolic syndrome.
- A high ratio combined with elevated HOMA-Index and HbA1c (NGSP) strengthens the link to metabolic dysfunction.
- The ratio falls with omega-3 supplementation and improves the AA / EPA Ratio in parallel.
How often should I test AA / DGLA ratio?
Most adults benefit from yearly AA/DGLA ratio testing as part of a fatty acid panel. After a sustained change in diet or supplementation, retest at 3 to 4 months.
At baseline / for screening: Once every 12 months as part of a fatty acid panel. More frequently, every 3 to 6 months, if you're managing a cardiometabolic concern where fatty acids matter.
When monitoring an intervention or change: Retest 3 to 4 months after a sustained change in dietary fat, such as increasing fatty fish, omega-3 supplements (EPA/DHA), or reducing seed oils. Red cell membranes take this long to fully reflect the new intake. Day-to-day variability is minimal, so only sustained dietary patterns shift the picture meaningfully; don't expect quick changes from short-term diet shifts.
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