Arachidonic acid (omega-6, AA)
Omega fatty acidsAlso known as: AA, omega-6 arachidonic, omega
AA is a polyunsaturated omega-6 fatty acid that serves as a precursor to numerous pro-inflammatory and vasoactive mediators.
Why this matters
While essential for cell signaling and immune function, excessive Arachidonic Acid (AA) relative to omega-3s promotes chronic inflammation. Monitoring AA helps balance pro- and anti-inflammatory lipid pathways.
How this connects to other biomarkers
- Arachidonic Acid is the precursor to pro-inflammatory eicosanoids (PGE2, LTB4, TXA2) and is balanced against Eicosapentaenoic Acid (20:5, EPA) in the AA / EPA Ratio.
- Elevated AA with high AA / DGLA Ratio indicates active conversion to pro-inflammatory pathways; pair with hs-CRP to gauge clinical impact.
How often should I test Arachidonic acid (omega-6, AA)?
Most adults benefit from yearly arachidonic acid (AA) testing as part of a fatty acid panel. After a sustained change in diet or supplementation, retest at 3 to 4 months.
At baseline / for screening: Once every 12 months as part of a fatty acid panel. More frequently, every 3 to 6 months, if you're managing a cardiometabolic concern where fatty acids matter.
When monitoring an intervention or change: Retest 3 to 4 months after a sustained change in dietary fat, such as increasing fatty fish, omega-3 supplements (EPA/DHA), or reducing seed oils. Red cell membranes take this long to fully reflect the new intake. Day-to-day variability is minimal, so only sustained dietary patterns shift the picture meaningfully; don't expect quick changes from short-term diet shifts.
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