Lipoprotein (a)
CardiovascularA genetically determined cholesterol particle, similar to LDL but carrying an extra protein called apolipoprotein(a).
Lp(a) helps transport cholesterol but can drive the build-up of plaque in the arteries and promote blood clotting. Because your level is largely inherited and stays fairly stable throughout life, a single measurement usually tells you your lifelong risk. A high Lp(a) raises the risk of heart attack and stroke and typically causes no symptoms until a cardiovascular event occurs. Since diet and standard cholesterol-lowering medications have limited effect on Lp(a) itself, knowing your level helps you control the risk factors you can change more tightly, such as LDL cholesterol, blood pressure, and smoking.
How often should I test Lipoprotein (a)?
Because Lp(a) is genetically set and stays largely stable throughout life, most people only need it measured once, usually as part of an initial cardiovascular risk assessment. A repeat is worth considering only if the first result was borderline, was taken during pregnancy or an acute illness, or if you start a therapy aimed specifically at lowering Lp(a).
At baseline / for screening: Once in a lifetime for most adults, as part of a first cardiovascular risk assessment.
When monitoring an intervention or change: Routine retesting is not needed, as levels are inherited and stable. Repeat only if the first result was borderline, was taken during pregnancy or acute inflammation, or if you begin a therapy that targets Lp(a) directly.
Note: Lp(a) can be temporarily raised by pregnancy, acute inflammation, or kidney disease, so an isolated high reading in those situations may be worth repeating once you have recovered.
Frequently asked questions
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